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Proparacaine Hydrochloride (5875-06-9)

Proparacaine Hydrochloride(Proparacaine HCL) is a topical anesthetic prepared as a sterile aqueous ophthalmic solution. Each mL contains: Active: Proparacaine Hydrochloride 0.5% (5 mg). Preservative: Benzalkonium Chloride 0.01%. Inactive: Glycerin, Hydrochloric Acid and/or Sodium Hydroxide (to adjust pH), Purified Water.

What is Proparacaine hydrochloride anesthetic raw powder?

Proparacaine Hydrochloride,also known as brand name ALCAINE (proparacaine hydrochloride ophthalmic solution) on the market, is a topical anesthetic prepared as a sterile aqueous ophthalmic solution. Each mL contains: Active: Proparacaine Hydrochloride 0.5% (5 mg). Preservative: Benzalkonium Chloride 0.01%. Inactive: Glycerin, Hydrochloric Acid and/or Sodium Hydroxide (to adjust pH), Purified Water.

What is Proparacaine hydrochloride powder?

Proparacaine hydrochloride raw powder,is the raw material of Proparacaine hydrochloride,a kind of White crystalline powder.CAS: 5875-06-9, Molecular Formula:C16H27ClN2O3,Molecular Weight:330.85,Storage Temp:RT.

What is Proparacaine hydrochloride anesthetic raw powder used for?

Proparacaine (HCl) is primarily indicated in conditions like Anesthesia.

For procedures in which a topical ophthalmic anesthetic is indicated: corneal anesthesia of short duration (eg, tonometry, gonioscopy, removal of corneal foreign bodies), and for short corneal and conjunctival procedures

Also it can also be given in adjunctive therapy as an alternative drug of choice in Cataract, Glucoma.

How does Proparacaine Hydrochloride anesthetic raw powder works?

Proparacaine Hydrochloride Ophthalmic Solution is a rapid acting local anesthetic suitable for ophthalmic use. With a single drop, the onset of anesthesia begins within 30 seconds and persists for 15 minutes or longer.

The main site of anesthetic action is the nerve cell membrane where proparacaine interferes with the large transient increase in the membrane permeability to sodium ions that is normally produced by a slight depolarization of the membrane. As the anesthetic action progressively develops in a nerve, the threshold for electrical stimulation gradually increases and the safety factor for conduction decreases; when this action is sufficiently well developed, block of conduction is produced.

The exact mechanism whereby proparacaine and other local anesthetics influence the permeability of the cell membrane is unknown; however, several studies indicate that local anesthetics may limit sodium ion permeability by closing the pores through which the ions migrate in the lipid layer of the nerve cell membrane. This limitation prevents the fundamental change necessary for the generation of the action potential.

Recommend dosage of Proparacaine Hydrochloride anesthetic raw powder

Deep anesthesia as in cataract extraction:

Instill 1 drop to the eye every 5 to 10 minutes for 5 to 7 doses.

Removal of sutures:

Instill 1 or 2 drops to the eye 2 or 3 minutes before removal of stitches.

Removal of foreign bodies:

Instill 1 or 2 drops to the eye prior to operating.


Instill 1 or 2 drops to the eye immediately before measurement.

Side Effects of Proparacaine Hydrochloride anesthetic raw powder

Pupillary dilatation or cycloplegic effects have rarely been observed with proparacaine hydrochloride. The drug appears to be safe for use in patients sensitive to other local anesthetics, but local or systemic sensitivity occasionally occurs. Instillation of proparacaine in the eye at recommended concentration and dosage usually produces little or no initial irritation, stinging, burning, conjunctival redness, lacrimation or increased winking. However, some local irritation and stinging may occur several hours after the instillation.

Rarely, a severe, immediate-type, apparently hyperallergic corneal reaction may occur which includes acute, intense and diffuse epithelial keratitis; a gray, ground-glass appearance; sloughing of large areas of necrotic epithelium; corneal filaments and, sometimes, iritis with descemetitis.

Allergic contact dermatitis with drying and fissuring of the fingertips has been reported.

Softening and erosion of the corneal epithelium and conjunctival congestion and hemorrhage have been reported.

The severe or irreversible adverse effects of Proparacaine Hydrochloride, which give rise to further complications include Cardiac arrhythmias, CNS depression, Hemorrhage, Keratitis, Conjunctival congestion.

The symptomatic adverse reactions produced by Proparacaine Hydrochloride are more or less tolerable and if they become severe, they can be treated symptomatically, these include Blurred vision, Redness, Burning, Diaphoresis, Contact dermatitis, Lacrimation, Stinging on application.

Warning of Proparacaine Hydrochloride anesthetic raw powder

For topical ophthalmic use only. Do not touch dropper tip to any surface as this may contaminate the solution. Prolonged use of a topical ocular anesthetic may produce permanent corneal opacification with accompanying loss of vision.

Proparacaine should be used cautiously and sparingly in patients with known allergies, cardiac disease, or hyperthyroidism. The long-term toxicity of proparacaine is unknown; prolonged use may possibly delay wound healing. Although exceedingly rare with ophthalmic application of local anesthetics, it should be borne in mind that systemic toxicity (manifested by central nervous system stimulation followed by depression) may occur.

Also you'd better not use the drug if you are

Pregnanct or Nursing Mothers

For Pediatric Use

It is not known whether this drug is excreted in human milk or for Pediatric use. Because many drugs are excreted in human milk, caution should be exercised when proparacaine hydrochloride is administered to a nursing woman.

How should Proparacaine Hydrochloride anesthetic raw powder be stored?

Refrigerate at 2° to 8°C (36° to 46°F). Keep bottle tightly closed. Store in carton until empty to protect from light. If solution shows more than a faint yellow color, it should not be used.

Warning — keep this and all this drugs out of the reach of Children.

How to buy high purity Proparacaine Hydrochloride powder from SZOB?

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