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Diabetic Men Taking Vs Not Taking Drugs For Erectile Dysfunctiona

Animal studies have shown that PDE5 inhibitors are cardioprotective and reduce arrhythmias, Dr Anderson explained. However, this has not been well studied in humans. The researchers aimed to determine whether men with type 2 diabetes who were taking PDE5 inhibitors had improved survival.

The first trial, a retrospective analysis of data from 42 general practices in Cheshire, United Kingdom, included 7860 men aged 40 to 89 who had been diagnosed with type 2 diabetes prior to January 1, 2007 and who were followed for about 5 years.

A total of 1359 men (22.8%) had been prescribed a PDE5 inhibitor.

PDE5 inhibitors licensed for use in the United Kingdom include sildenafil (Viagra, Pfizer), tadalafil (Cialis, Lilly/ICOS), and vardenafil (Levitra, Bayer/GlaxoSmithKline).

This group had a lower risk of dying during the 5-year follow-up compared with their peers who did not receive a PDE5 inhibitor (18% vs 25%).

And even after adjustment for multiple confounders — age, estimated glomerular filtration rate (eGFR), history of MI, smoking, systolic blood pressure, and use of a statin, beta-blocker, aspirin, and metformin — the men who were taking a drug for erectile dysfunction still had a lower risk of dying from all causes during follow-up (hazard ratio [HR], 0.83; P = .038).

And notably, in the cohort of 432 men who had a new MI during follow-up, those who had been receiving a PDE5 inhibitor were 38% less likely to die from the MI, compared with their peers, after adjustment for the same multiple confounders (HR, 0.62; P = .001).

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