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Letrozole(Femara) powder (112809-51-5)

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1. What Is Raw Letrozole(Femara) powder?


Letrozole is an anti-estrogen of the Aromatase Inhibitor (AI) family and is one of the most potent and powerfully effective of all AI’s. In fact, its potency is sometimes too much for some to handle when used for off label use. Letrozole first gained U.S. FDA approval in 1997 and would hit the market under the brand name Femara through Novartis. Although Femara is the dominating trade name of the AI, unlike most AI’s it is the only one generally known by its chemical name Letrozole far more commonly than its dominating brand name.

 

Letrozole was first developed in an effort to combat breast cancer in post-menopausal women. In fact, it would prove to be virtually identical to the already popular AI in Arimidex (Anastrozole). While intended for breast cancer treatment, like many AI’s, it has found a welcomed home among anabolic steroid users. Letrozole is one of the most commonly used anti-estrogens among steroid users during steroid use to combat possible estrogenic related side effects. It is so effective as an anti-estrogen in this regard many anabolic steroids have effectively reversed gynecomastia symptoms with Letrozole.

 

Letrozole is used treat early breast cancer in women who have experienced menopause (change of life; end of monthly menstrual periods) and who have had other treatments, such as radiation or surgery to remove the tumor. It is also used to treat early breast cancer in women who have experienced menopause and who have already been treated with a medication called tamoxifen (Nolvadex) for 5 years. 


Letrozole is also used in women who have experienced menopause as a first treatment of breast cancer that has spread within the breast or to other areas of the body or in women whose breast cancer has worsened while they were taking tamoxifen. Letrozole is in a class of medications called nonsteroidal aromatase inhibitors. It works by decreasing the amount of estrogen produced by the body. This can slow or stop the growth of some types of breast cancer cells that need estrogen to grow.




 

2. How Does Raw Letrozole(Femara) powder Works?


Letrozole is an AI, which holds the purpose of blocking the aromatase enzyme, which is in turn responsible for the production of estrogen. By inhibiting estrogen production, this lowers total serum estrogen levels in the body. This will be useful to the breast cancer patient on the basis of such cancer often feeding off the estrogen hormone. It will be beneficial to the anabolic steroid user as excess estrogen often leads to some of the most commonly associated side effects of anabolic steroid use.

 

Letrozole also carries the ability to increase natural testosterone production through an increase in Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH). There have been physicians who have chosen Letro as it’s often known to treat low testosterone conditions, but this is normally not the preferred method of treatment. 


Without question, when it comes to low testosterone treatment exogenous testosterone is generally the only thing that makes sense. However, Letrozole can be useful in such a plan in conjunction with exogenous testosterone in order to combat possible side effects. We will look into this in the effects section.

 

Letrozole lowers the levels of the female sex hormone oestrogen in the body. Oestrogen stimulates some breast cancers to grow. These breast cancers are called hormone sensitive or hormone receptor positive. Letrozole can stop or slow the growth of these cancers.

 

After the menopause, women don't produce oestrogen from their ovaries. But they still produce a small amount by using an enzyme called aromatase which turns other sex hormone called androgens into oestrogen. This change happens mainly in fatty tissue, muscle and the skin. Letrozole is a type of drug called an aromatase inhibitor. It blocks aromatase so that it can't change the androgen into oestrogen.

 

Hormones are chemical substances that are produced by glands in the body, which enter the bloodstream and cause effects in other tissues.For example, the hormone testosterone made in the testicles and is responsible for male characteristics such as deepening voice and increased body hair. 


The use of hormone therapy to treat cancer is based on the observation that receptors for specific hormones that are needed for cell growth are on the surface of some tumor cells.Hormone therapies work by stopping the production of a certain hormone, blocking hormone receptors, or substituting chemically similar agents for the active hormone, which cannot be used by the tumor cell.  The different types of hormone therapies are categorized by their function and/or the type of hormone that is effected.





3.How to Use Raw Letrozole(Femara) powder?


Letrozole as an anti-estrogen is extremely beneficial to breast cancer patients. Many forms of breast cancer actively feed off the estrogen hormone. By inhibiting the production of estrogen, which in turn lowers the amount of circulating estrogen in the body, this has the ability to starve the cancer. 


For years Nolvadex was the preferred form of treatment for this purpose. Nolvadex actively binds to the estrogen receptor, thereby preventing estrogen from binding. However, it does not inhibit or lower production. Nolvadex is still extremely valuable in breast cancer treatment plans, but many physicians, especially in extreme cases have begun to use AI’s first. Once the cancer is in remission, at this stage a SERM like Nolvadex may replace the AI in an effort to protect against the cancer reappearing.

 

For the anabolic steroid user, the same anti-estrogenic effect provided by Letrozole is tremendously beneficial. Many anabolic steroids have the ability to increase estrogen levels due to testosterone’s interaction with the aromatase enzyme. As estrogen levels rise, this can lead to gynecomastia and excess water retention. 


If water retention becomes severe, this can in turn promote high blood pressure. While many anabolic steroids have the ability to aromatize and promote an increase in estrogen, not all anabolic steroids carry this ability. However, many common steroids carry this ability including Methandrostenolone (Dianabol) as well as all forms of testosterone. The Nandrolone (Deca Durabolin, Durabolin, NPP, etc.) and Boldenone (Equipoise) hormone also carry the ability to aromatize to a degree. 


Nandrolone will aromatize at approximately 20% the rate of testosterone and Boldenone at approximately 50%. While both aromatize significantly less than testosterone, it is enough to promote estrogenic related side effects. The probability is increased with Nandrolone as it carries a strong progestin nature. Progesterone has the ability to stimulate the estrogenic mechanism and can lead to gynecomastia. AI’s like Letrozole can be useful when using all the aforementioned steroids.




By including Letrozole in a cycle that contains aromatizing anabolic steroids, this can prevent the estrogenic related side effects. This will protect the individual from gynecomastia and water retention. Further, while many steroids can promote high blood pressure despite aromatization, an AI will improve the individual’s odds when water retention is the culprit. Heavy excess water retention is normally the number one cause of high blood pressure among steroid users.

 

Undeniably, AI’s like Letrozole are the most effect means at combating estrogenic related side effects. However, they can also have a negative impact on cholesterol. Alone AI’s do not appear to have a strong, negative effect on cholesterol, but when coupled with an aromatizing steroid like testosterone the adverse cholesterol effect is enhanced. 


For this reason, many will find SERM’s like Tamoxifen Citrate (Nolvadex) should be their first choice in estrogen protection. SERM’s will not negatively affect cholesterol; in fact, SERM’s, while anti-estrogenic, actively act as estrogens in the liver, and in turn, promote healthier cholesterol levels. We’ll look at this in more detail in the side effect section, and while Letrozole can be used without an adverse cholesterol effect, it will take some effort on your part.


With its ability to promote natural testosterone production, Letrozole is often an appealing choice for Post Cycle Therapy (PCT) plans. This can also make it appealing for low testosterone treatment, but it’s often not enough. However, for PCT purposes, while it can be effective it’s generally not recommended. The primary purpose of PCT is stimulating natural testosterone production, which Letrozole can do very well. 


However, part of the purpose of PCT is also normalization, which will be difficult with severely suppressed estrogen levels. Estrogen is an important hormone as it promotes a stronger immune system and healthier cholesterol levels. For the anabolic steroid user, his best bet for PCT is sticking with SERM’s for his natural testosterone production needs.




 

4. Dosage of Raw Letrozole(Femara) powder


Usual Adult Dose for Breast Cancer

2.5 mg orally once a day

 

Duration of Therapy:

-Adjuvant and Extended Adjuvant Settings: Optimal duration is unknown; discontinue treatment at relapse.

-Advanced Disease: Until tumor progression is evident.

 

Uses:

-Adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer.

-Extended adjuvant treatment of early breast cancer in postmenopausal women who have received 5 years of adjuvant tamoxifen therapy.

-First-line treatment of advanced breast cancer in postmenopausal women with hormone receptor positive or unknown locally advanced or metastatic breast cancer; second-line treatment of advanced breast cancer in postmenopausal women with disease progression following antiestrogen therapy.

 

Usual Adult Dose for Breast Cancer - Adjuvant

2.5 mg orally once a day

 

Duration of Therapy:

-Adjuvant and Extended Adjuvant Settings: Optimal duration is unknown; discontinue treatment at relapse.

-Advanced Disease: Until tumor progression is evident.

 

Uses:

-Adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer.

-Extended adjuvant treatment of early breast cancer in postmenopausal women who have received 5 years of adjuvant tamoxifen therapy.

-First-line treatment of advanced breast cancer in postmenopausal women with hormone receptor positive or unknown locally advanced or metastatic breast cancer; second-line treatment of advanced breast cancer in postmenopausal women with disease progression following antiestrogen therapy.

 

In the treatment of breast cancer, the standard Letrozole dose will normally be 2.5mg per day. This is an extremely potent dose and will normally be administered until the cancer subsides. In many cases, at the point of remission the patient will switch from Letrozole to Nolvadex in a preventative treatment plan scenario.

 

For the anabolic steroid user, Letrozole doses will normally be much lower. Even with the use of anabolic steroids, a 2.5mg dosing will normally be too high and could potentially drain the individual of energy; in fact, it’s almost guaranteed. The only exception we could make for such a dose would be to combat early gynecomastia symptoms. 


If symptoms begin to show 7-14 days at a dose of 2.5mg per day can reverse the symptoms. Once symptoms begin to fade away the individual should be able to tapper down to a more manageable dose and maintain it for the remainder of the cycle. If this doesn’t work there’s a good chance the symptoms have already set in beyond remedy. When this happens the only thing that will remove your gynecomastia is surgery. 


For standard estrogenic related protection, most men will find 0.5-1mg every other day to be more than enough. When used as an anti-estrogen in low testosterone treatment plans, even less may be needed. For the competitive bodybuilder, the final 7-14 days before competition, a full 1mg per day leading up to the show can be a solid dose and will greatly help with dryness and a tighter look. This is, however, not a dose most would want to maintain for an extended period of time as it can be harsh.




 

5. Warning of Raw Letrozole(Femara) powder


Before taking letrozole,

tell your doctor and pharmacist if you are allergic to letrozole, any other medications, or any of the ingredients in letrozole tablets. Ask your pharmacist for a list of the ingredients.


tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: medications that contain estrogen such as hormone replacement therapy (HRT) and hormonal contraceptives (birth control pills, patches, rings, and injections); raloxifene (Evista); and tamoxifen (Nolvadex).


tell your doctor if you have high cholesterol, osteoporosis (condition in which the bones are fragile and break easily), or liver disease.


you should know that letrozole should only be taken by women who have experienced menopause and cannot become pregnant. However, if you are pregnant or breast-feeding, you should tell your doctor before you begin taking this medication. Letrozole may harm the fetus.


you should know that letrozole may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.

 

Tell all of your health care providers that you take this medicine. This includes your doctors, nurses, pharmacists, and dentists.


Avoid driving and doing other tasks or actions that call for you to be alert until you see how letrozole affects you.


This medicine may cause weak bones. This may happen more often if used for a long time. This may raise the chance of broken bones. Call your doctor right away if you have bone pain.

Have a bone density test as you have been told by your doctor. Talk with your doctor.

Have blood work checked as you have been told by the doctor. Talk with the doctor.

Take calcium and vitamin D as you were told by your doctor.


If you are 65 or older, use this medicine with care. You could have more side effects.

This medicine may affect fertility. Fertility problems may lead to not being able to get pregnant or father a child. Talk with the doctor.


This medicine may cause harm to the unborn baby if you take it while you are pregnant.

If you are able to get pregnant, a pregnancy test will be done to show that you are NOT pregnant before starting letrozole. Talk with your doctor.


Use birth control that you can trust to prevent pregnancy while taking this medicine and for at least 3 weeks after your last dose.


If you get pregnant while taking letrozole or within 3 weeks after your last dose, call your doctor right away.





6. What Are the Possible Side Effects of Letrozole(Femara) raw powder?


The side effects of Letrozole will cover a wide breadth and will be very similar to Arimidex. Both weakness and fatigue are two of the most common side effects of Letrozole use. However, for the anabolic steroid user this will normally not be an issue. 


The use of anabolic steroids should prevent such states so as long as estrogen suppression isn’t taken too far. The exception would be its use during a hard bodybuilding contest prep cycle. During a harsh bodybuilding diet, the individual will normally be very weak and fatigue at the end of his diet due to tremendously intense training and very low caloric intake. Beyond possible energy issues, the most common side effects of Letrozole use include:


Headaches

High Blood Pressure

Hot Flashes

Joint Pain

Depression

Letrozole has also been shown to have the ability to notably decrease bone mineral content, which could increase the risk of osteoporosis. This should, however, not be a big risk for the anabolic steroid as most steroids have the ability to promote bone mineral content to a degree, especially Nandrolone. 


As with all medications and anything we put into our body, the side effects of Letrozole will largely surround possible and not guaranteed. We are all different and respond to varying substances differently. This is something you need to keep in mind, and if the side effects of Letrozole prove to be too much to handle, alternative medications should be looked at.




The final side effect of Letrozole surrounds cholesterol, specifically a reduction in HDL cholesterol. Alone it does not appear to have a strong, statistical impact, but for the anabolic steroid user this can be a concern. Many anabolic steroids already have the ability to negatively affect cholesterol, and when conjoined with an AI it appears to be greatly exasperated. 


Studies have shown that therapeutic doses of testosterone have very little negative effect on cholesterol but the same doses can suppress HDL cholesterol by as much as 25% when combined with an AI. When testosterone is administered at a supraphysiological level, a minimal level of HDL suppression is normally expected. When the same dosing level is conjoined with an AI data shows that a 20% or greater suppression of HDL cholesterol is a very real possibility.

 

Due to the possible adverse effects on cholesterol, especially for the anabolic steroid user, a cholesterol friendly lifestyle becomes imperative. A healthy lifestyle will greatly revolve around your diet. Simple sugars and saturated fats should be limited and omega fatty acids should be a large part of your diet. 


Daily fish oil supplementation is recommended. Many may also find a cholesterol antioxidant supplement to be useful. Further, implementing plenty of cardiovascular activity into your routine is very important. Some type of daily cardiovascular activity is advised.

 

Because of the potential cholesterol issues, many anabolic steroid users will need to use SERM’s to combat estrogenic side effects when possible. SERM’s won’t always get the job done, but they can work and will work a lot better than many steroid users believe. If an AI is needed, some have suggested that a daily dose of Nolvadex at 10mg per day with your AI could help protect cholesterol levels due to SERM’s actively promoting healthier cholesterol levels.



 

 

7. Buy Letrozole(Femara) powder from SZOB


 Visit our online pharmacy and fill in an order of Letrozole raw materials.

 Define place of delivery, quantity of the product and the way of payment.

 In the period of 30 minutes, you will receive a confirmation of your order.

 It will be sent out within 12 hours.

 



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