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Flibanserlin HCL powder (147359-76-0)

Flibanserlin HCL powder (147359-76-0)

Flibanserin Hydrochloride powder, Flibanserin Hydrochloride raw powder, buy Flibanserin Hydrochloride powder, raw Flibanserin Hydrochloride powder, Flibanserin Hydrochloride powder for sale, Flibanserin Hydrochloride powder supplie, Flibanserlin HCL powder,buy Flibanserlin HCL powder, Flibanserlin HCL powder for sale, Flibanserlin HCL powder supplie,

1. What Is Raw Flibanserin Hydrochloride powder?

Flibanserin Hydrochloride is a central nervous system agent used to treat low sexual desire disorder in women who have not gone through menopause. Flibanserin Hydrochloride is a medication for the treatment of pre-menopausal women with hypoactive sexual desire disorder (HSDD),the way it works is similar to Flibanserin,also has same side effects with Flibanserin,Compared with Flibanserin, the differences are Flibanserin Hydrochloride is more effective,cheaper on price.


Raw Flibanserin Hydrochloride powder?

Flibanserin Hydrochloride raw powder,the material of Flibanserin Hydrochloride,a kind of White or off white or light yellow crystalline powder,many steroids products supplier usually buy high purity Flibanserin Hydrochloride powder online,make it into all kinds of brand finished Flibanserin Hydrochloride,the detail of the Flibanserin Hydrochloride raw in SZOB as below:

Name: Flibnaserin Hydrochloride

CAS: 147359-76-0

Molecular Formula: C20H21F3N4O·CIH

Molecular Weight: 344.49

Melt Point: 118℃

Storage Temp.: RT

Color: White or off white or light yellow crystalline powder


2. Raw Flibanserin Hydrochloride powder Works?

Flibanserin Hydrochloride works on three important brain chemicals: dopamine, norepinephrine, and serotonin. These chemicals are neurotransmitters. They are responsible for sending signals between the brain and other parts of the body through the nervous system.

Dopamine and norepinephrine are involved with sexual excitement. However, serotonin contributes to sexual inhibition and may dampen sex drive. It is thought that if these chemicals are out of balance – if dopamine and norepinephrine levels are too low and/or serotonin levels are too high – a woman might feel less sexual desire.

Flibanserin Hydrochloride works by raising levels of dopamine and norepinephrine while lowering levels of serotonin. In this way, chemicals that help promote sexual desire are increased and one that can suppress desire is decreased.

Flibanserin Hydrochloride Application:

Flibansetrin hcl has high affinity for serotonin receptors in the brain: it acts as an agonist on 5-HT1A and an antagonist on 5-HT2A. In vivo, flibanserin binds equally to 5-HT1A and 5-HT2A receptors. However, under higher levels of brain 5-HT (i.e., under stress), Flibanserin Hydrochloride may occupy 5-HT2A receptors in higher proportion than 5-HT(1A) receptors. It may also moderately antagonize D4 (dopamine) receptors and 5-HT2B and 5-HTB2C. Its action on neurotransmitter receptors may contribute to reduction in serotonin levels and increase in dopamine and norepinephrine levels, all of which may play part in reward processing.


Medical uses

Flibanserin Hydrochloride is used for hypoactive sexual desire disorder among women. Those receiving Flibanserin Hydrochloride report a 0.5 increase compared to placebo in the number of times they had "satisfying sexual events". In those on flibanserin it rose from 2.8 to 4.5 times a month while women receiving placebo reported also an increase of "satisfying sexual events" from 2.7 to 3.7 times a month.The onset of the flibanserin effect was seen from the first timepoint measured after 4 weeks of treatment and maintained throughout the treatment period.


The effectiveness of Flibanserin Hydrochloride was evaluated in three phase 3 clinical trials. Each of the three trials had two co-primary endpoints, one for satisfying sexual events (SSEs) and the other for sexual desire. Each of the 3 trials also had a secondary endpoint that measured distress related to sexual desire. All three trials showed that flibanserin produced an increase in the number of SSEs and reduced distress related to sexual desire. The first two trials used an electronic diary to measure sexual desire, and did not find an increase. These two trials also measured sexual desire using the Female Sexual Function index (FSFI) as a secondary endpoint, and an increase was observed using this latter measure. The FSFI was used as the co-primary endpoint for sexual desire in the third trial, and again showed a statistically significant increase.


Is Flibanserin Hydrochloride really effective?

It's not like there's a blood test for female sexual desire; how much you desire sex is a purely subjective measure (compared to Viagra, which changes measurable factors like strength and duration of an erection, Thorp says). But even if the effects are small by the FDA's interpretation, they could make a world of difference to the right woman, says Leah S. Millheiser, MD, clinical assistant professor in obstetrics and gynecology and director of the Female Sexual Medicine Program at Stanford University School of Medicine. "If I said to her, 'I can improve your libido by one to two sexual events per month,' that's already tremendously impacted her self-esteem in her relationship," she says. This hasn't always convinced everyone on advisory panels, Thorp says, namely men who consider one to two additional satisfying sexual encounters a month to be pretty trivial.


3. How to Use Raw Flibanserin Hydrochloride powder?

Before taking Flibanserin Hydrochloride

You must not drink alcohol while taking Flibanserin Hydrochloride. It may cause you to have dangerously low blood pressure.You should not use Flibanserin Hydrochloride if you are allergic to Flibanserin Hydrochloride, or if you have:

low blood pressure;

a history of alcoholism or drug addiction;

liver disease;

a history of depression or mental illness; or

if you currently drink alcohol.

Some medicines can cause unwanted or dangerous effects when used with Flibanserin Hydrochloride.


Your doctor may need to change your treatment plan if you use any of the following drugs:


an antibiotic - ciprofloxacin, clarithromycin, erythromycin, telithromycin;

antifungal medicine - fluconazole, itraconazole, ketoconazole, posaconazole;

antiviral medicine to treat hepatitis C - boceprevir, telaprevir;

heart or blood pressure medicine - conivaptan, diltiazem, verapamil; or

HIV or AIDS medicine - atazanavir, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir.


To make sure Flibanserin Hydrochloride is safe for you, tell your doctor if you have:

history of alcoholism or drug addiction.

It is not known whether Flibanserin Hydrochloride will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether Flibanserin Hydrochloride passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Flibanserin Hydrochloride is not approved for use by anyone younger than 18 years old.


While you taking Flibanserin Hydrochloride

while you take Flibanserin Hydrochloride,please avoid doing following things: 

Do not drink alcohol while taking Flibanserin Hydrochloride. Drinking alcohol with this medicine can cause dangerous or unwanted side effects.

Grapefruit and grapefruit juice may interact with flibanserin nd lead to unwanted side effects. Avoid the use of grapefruit products while taking Addyi.

Avoid taking an herbal supplement containing: ginkgo, resveratrol, or St. John's wort.

Flibanserin Hydrochloride may impair your thinking or reactions. Avoid driving or operating machinery for at least 6 hours after you take this medicine, and until you know how this medicine will affect you. Dizziness or low blood pressure can cause falls or other accidents.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.


After you taking Flibanserin Hydrochloride

After taking Flibanserin Hydrochloride,it's important to hopw how to store and dispose it,now let's learn.

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location one that is up and away and out of their sight and reach.

What are Flibnaserin Hydrochloride drug interactions?

Oral Contraceptives and Other Weak CYP3A4 Inhibitors

These drugs can increase  the concentration of Addyi  resulting in a higher risk for adverse reactions. Common weak CYP3A4 inhibitors include oral contraceptives, cimetidine, fluoxetine, Ginko Biloba, and  ranitidine.


Strong CYP2C19 Inhibitors

Strong  CYP2C19 inhibitors can also increase the concentration of  Addyi. Common CYP2C19 inhibitors are proton pump inhibitors (e.g., Prilosec), selective serotonin reuptake inhibitors (e.g., Prozac), benzodiazepines, and antifungals.


CYP3A4 Inducers

Flibnaserin Hydrochlorideconcentrations are substantially reduced by CYP3A4 inducers. The use of ADDYI with a CYP3A4 inducer is not recommended. Common CYP3A4 inducers include carbamazepine, rifampin, rifapentine, and St. Johns Wort.



Concomitant use of Flibnaserin Hydrochlorideand digoxin will increase digoxin concentrations. Digoxin concentrations should be monitored while on Flibnaserin Hydrochloride.


Alcohol and CYP3A4 Inhibitors

Flibnaserin Hydrochloride is contraindicated with alcohol consumption, moderate or strong CYP3A4 inhibitors and hepatic impairment. Concomitant use of alcohol  increased the risk of hypotension, syncope and CNS depression. The use of Moderate or strong CYP3A4 inhibitors increased  the risk of hypotension and syncope


Moderate CYP3A4 inhibitors include: amprenavir, atazanavir, ciprofloxacin, diltiazem, erythromycin, fluconazole, fosamprenavir, verapamil, and grapefruit juice


Strong CYP3A4 inhibitors include: ketoconazole, itraconzole, posaconazole, clarithromycin, nefazodone, ritonavir, saquinavir, nelfinavir, indinavir, boceptrevir, telaprevir, telithromycin, and conivaptan


Liver impairment: any degree of hepatic impairment can lead to a 4.5-fold increase in Flibnaserin Hydrochloride concentrations.


4. Dosage of Raw Flibanserin Hydrochloride powder

Recommend dosage of Flibnaserin Hydrochloride

Take Flibnaserin Hydrochloride exactly as prescribed.Flibnaserin Hydrochloride comes in tablet form and is taken once daily, at bedtime,100 mg taken once a day.

Take Flibnaserin Hydrochloride only at bedtime. Taking Flibnaserin Hydrochloride at a time other than bedtime can increase your risk of low blood pressure, fainting (loss of consciousness), accidental injury, and sleepiness.


What happens if I miss a dose?

If you miss a dose of Flibnaserin Hydrochloride , skip your missed dose. Take your next dose at bedtime the next day. Do not take Flibnaserin Hydrochloride   the next morning or double your next dose. If you take too much Flibnaserin Hydrochloride  , call your doctor.


What happens if I overdose?

If you take too much Flibnaserin Hydrochloride, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away. call the Poison Help line at 1-800-222-1222.


Tell your doctor if your symptoms of HSDD have not improved after you have taken Flibnaserin Hydrochloride for 8 weeks.


5. Warning of Raw Flibanserin Hydrochloride powder

Do not drink alcohol while takingFlibnaserin Hydrochloride,.Use of Flibnaserin Hydrochloride,and alcohol increases the risk of severe hypotension and syncope; therefore, alcohol use is contraindicated.


Severe hypotension and syncope can oalso ccur when Flibnaserin Hydrochloride, is used with moderate or strong CYP3A4 inhibitors or in patients with hepatic impairment; therefore, Flibnaserin Hydrochloride,use in these settings is contraindicated.


Flibnaserin Hydrochloride is only available through the Flibnaserin Hydrochloride risk evaluation and mitigation strategy (REMS) Program because of the increased risk of severe low blood pressure and fainting (loss of consciousness) with alcohol use. You can only get Flibnaserin Hydrochloride, from pharmacies that are enrolled in the Flibnaserin Hydrochloride, REMS Program.


6. What Are the Possible Side Effects of Raw Flibanserin Hydrochloride powder?


Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.


More common

Blurred vision


dizziness, fainting, or lightheadedness, especially when getting up suddenly from a lying or sitting position


l unusual tiredness or weakness

sleepiness or unusual drowsiness


Less common

Feeling of constant movement of self or surroundings

sensation of spinning






severe cramping

stomach or lower abdominal pain


Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them


7. Buy Flibnaserin Hydrochloride Powder from SZOB

How to buy Pharmaceutical Grade Flibnaserin Hydrochloride powder from SZOB raw company?

→ Visit our online pharmacy and fill in an order of Flibnaserin Hydrochlorideraw materials.

→ Define place of delivery, quantity of the product and the way of payment.

→ In the period of 30 minutes, you will receive a confirmation of your order.

→ It will be sent out within 12 hours.

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