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Bupivacaine HCL (14252-80-3)

Bupivacaine HCL(14252-80-3)anesthetic raw powder is an anesthetic (numbing medicine) that blocks the nerve impulses that send pain signals to your brain.It is used as a local (in only one area)anesthetic.Bupivacaine is given as an epidural injection into the spinal column to produce numbness during labor, surgery, or certain medical procedures.Bupivacaine is also used as an anesthetic for dental procedures.Bupivacaine may also be used for purposes not listed in this medication guide.

Bupivacaine HCL anesthetic raw powder

Bupivacaine hcl is a long-acting local anaesthetic. Addition of epinephrine is thus rarely required. It blocks initiation and transmission of nerve impulses at the site of application by stabilizing the neuronal membrane. The compound is ultimately metabolized in the liver. Depending upon the site of injection and the concentration used, anaesthesia usually lasts 2-4 hours.

 Dosage of Bupivacaine HCL anesthetic raw powder

The dose of any local anesthetic administered varies with the anesthetic procedure, the area to be anesthetized, the vascularity of the tissues, the number of neuronal segments to be blocked, the depth of anesthesia and degree of muscle relaxation required, the duration of anesthesia desired, individual tolerance, and the physical condition of the patient. The smallest dose and concentration required to produce the desired result should be administered. Dosages of Sensorcaine should be reduced for elderly and/or debilitated patients and patients with cardiac and/or liver disease. The rapid injection of a large volume of local anesthetic solution should be avoided and fractional (incremental) doses should be used when feasible.

For specific techniques and procedures, refer to standard textbooks.

There have been adverse event reports of chondrolysis in patients receiving intraarticular infusions of local anesthetics following arthroscopic and other surgical procedures. Sensorcaine is not approved for this use.

In recommended doses, Sensorcaine (bupivacaine HCl) produces complete sensory block, but the effect on motor function differs among the three concentrations.

0.25% - when used for caudal, epidural, or peripheral nerve block, produces incomplete motor block. Should be used for operations in which muscle relaxation is not important, or when another means of providing muscle relaxation is used concurrently. Onset of action may be slower than with the 0.5% or 0.75% solutions.

0.5% - provides motor blockade for caudal, epidural, or nerve block, but muscle relaxation may be inadequate for operations in which complete muscle relaxation is essential.

0.75% - produces complete motor block. Most useful for epidural block in abdominal operations requiring complete muscle relaxation, and for retrobulbar anesthesia. Not for obstetrical anesthesia.

The duration of anesthesia with Sensorcaine is such that for most indications, a single dose is sufficient.

Maximum dosage limit must be individualized in each case after evaluating the size and physical status of the patient, as well as the usual rate of systemic absorption from a particular injection site. Most experience to date is with single doses of Sensorcaine up to 225 mg with epinephrine 1:200,000 and 175 mg without epinephrine; more or less drug may be used depending on individualization of each case.

These doses may be repeated up to once every three hours. In clinical studies to date, total daily doses have been up to 400 mg. Until further experience is gained, this dose should not be exceeded in 24 hours. The duration of anesthetic effect may be prolonged by the addition of epinephrine.

The dosages in Table 1 have generally proved satisfactory and are recommended as a guide for use in the average adult. These dosages should be reduced for elderly or debilitated patients. Until further experience is gained, Sensorcaine is not recommended for pediatric patients younger than 12 years. Sensorcaine is contraindicated for obstetrical paracervical blocks, and is not recommended for intravenous regional anesthesia (Bier Block).

What should I avoid after receiving bupivacaine HCL anesthetic raw powder? 

This medication can cause numbness over a large portion of your body. Take care to avoid injury before the feeling has returned completely.

After a dental procedure, avoid eating, chewing gum, or drinking a hot beverage until your mouth is no longer numb.

Warnings of Bupivacaine HCL anesthetic raw powder:

0.75% concentration not recommended for obstetrical anesthesia: cardiac arrest with difficult resuscitation or death has occurred. To be administered under the supervision of experienced clinicians. Have intubation, artificial respiration, oxygen therapy and reversal agents available. Solns containing antimicrobial preservatives: do not use for epidural or caudal anesthesia. IV regional anesthesia (Bier Block): not recommended. Cardiovascular disease. Hepatic or renal impairment. Monitor cardiovascular and respiratory vital signs. Malignant hyperthermia. Head and neck administration. Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended.

What are the possible side effects of Bupivacaine HCL(14252-80-3)anesthetic raw powder?

Get emergency medical help if you have any of these signs of an allergic reaction: hives, red rash, itching; sneezing, difficulty breathing; severe dizziness, vomiting; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have any of these serious side effects:

  1. feeling anxious, restless, confused, or like you might pass out;

  2. problems with speech or vision;

  3. ringing in the ears, metallic taste, numbness or tingling around your mouth, or tremors;

  4. seizure (convulsions);

  5. weak or shallow breathing;

  6. fast heart rate, gasping, feeling unusually hot;

  7. slow heart rate, weak pulse;

  8. urinating less than usual or not at all.

Less serious side effects include:

  1. nausea, vomiting;

  2. chills or shivering;

  3. headache; or

  4. back pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect bupivacaine hcl anesthetic raw powder? 

Tell your doctor about all other medicines you use, especially:

  1. a blood thinner such as warfarin (Coumadin, Jantoven);

  2. ergot medicine such as ergotamine (Ergomar, Cafergot, Migergot), dihydroergotamine (D.H.E. 45, Migranal), ergonovine (Ergotrate), or methylergonovine (Methergine);

  3. antidepressants such as amitriptyline (Elavil, Vanatrip, Limbitrol), doxepin (Sinequan, Silenor), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), amitriptyline (Elavil, Vanatrip, Limbitrol), doxepin (Sinequan, Silenor), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), or trimipramine (Surmontil);

  4. an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate); or

  5. a phenothiazine such as chlorpromazine (Thorazine), fluphenazine (Permitil, Prolixin), perphenazine (Trilafon), prochlorperazine (Compazine, Compro), promethazine (Pentazine, Phenergan, Anergan, Antinaus), thioridazine (Mellaril), or trifluoperazine (Stelazine).

This list is not complete and other drugs may interact with bupivacaine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Buy bupivacaine hcl anesthetic raw powder online

Visit our online pharmacy and fill in an order of bupivacaine hcl anesthetic raw materials. Define place of delivery, quantity of the product and the way of payment. In the period of 30 minutes, you will receive a confirmation of your order. It will be delivered within 10 business days.

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